New cancer treatment slows aggressive neuroendocrine tumours: Study
![Simron Singh at Sunnybrook Health Sciences Centre](/sites/default/files/styles/news_banner_370/public/2024-06/Simron-Singh_99-220424d-crop.jpg?h=81d682ee&itok=19zYDIOx)
Simron Singh, a medical oncologist at Sunnybrook Health Sciences Centre and associate professor in the Temerty Faculty of Medicine, led a study that found that radioligand therapy reduces the risk of advanced neuroendocrine tumour progression and death (photo by Kevin Van Paassen, Sunnybrook)
Published: July 2, 2024
A novel approach for early cancer treatment known as radioligand therapy (RLT) has been shown to significantly reduce the risk of advanced neuroendocrine tumour progression and death, according to research led by scientists at Sunnybrook Health Sciences Centre and the 黄色直播.
Results of the multi-centre clinical trial, which were , provided evidence for the first time that RLT 鈥 when applied in the early stages after a patient鈥檚 diagnosis 鈥 slowed down the progression of aggressive grade 2 and 3 neuroendocrine tumours of the gastrointestinal tract.
The treatment was shown to extend the average time of 鈥減rogression-free survival鈥 from approximately 8.5 months to 22.8 months.
鈥淭his is the first study to show the effectiveness of RLT as the 鈥榝irst-line鈥 treatment with advanced uncurable cancer, or any cancer,鈥 said the study鈥檚 global principal investigator Simron Singh, a medical oncologist at Sunnybrook and associate professor in the department of medicine at 黄色直播鈥檚 Temerty Faculty of Medicine. 鈥淭his trial is groundbreaking not only for patients with neuroendocrine cancers, but for all cancer patients as it has implications for the practice of cancer treatment broadly.鈥
Singh described RLT as a 鈥済ame changer鈥 in the treatment of cancer, which has traditionally been carried out by surgery, drugs or radiation. 鈥淲hile it鈥檚 technically radiation, it is given via a chemotherapy route through the blood until it reaches the precise location of the tumour,鈥 said Singh, who is also an affiliate scientist at Sunnybrook Research Institute and co-founder of the Susan Leslie Clinic for Neuroendocrine Tumours at Sunnybrook鈥檚 Odette Cancer Centre.
RLT involves injecting radioactive isotopes 鈥 in this case, the drug Lutathera 鈥 through an IV. This method targets specific cancer cell receptors, delivering precise radiation to kill cancer cells while preserving healthy tissue.
The study evaluated the use of RLT earlier as a first-line (or 鈥渦p front鈥) treatment for patients newly diagnosed with grade 2 or 3 advanced gastrointestinal neuroendocrine tumours. Although neuroendocrine cancer is uncommon, incidence is rising rapidly, and few treatments exist for patients. This cancer is resistant to most therapies, making it challenging to treat.
The results confirm the clinical benefit of earlier use of RLT for patients diagnosed with aggressive and life-threatening tumours, said Singh. 鈥淭his is the next step in personalized targeted cancer therapy for patients, focused on more effectively killing cancer cells, while limiting the damage to surrounding healthy tissues.鈥
Further investigations of RLT as a therapeutic option are ongoing to evaluate overall survival and long-term safety, which will better define next steps for how this therapy will change cancer treatment world-wide.
The multi-site trial included investigators and participants from Canada, the United States, France, Germany, Italy, Netherlands, South Korea, Spain and the UK. An overview of the results was presented at the 2024 American Society of Clinical Oncology (ASCO) Gastrointestinal (GI) Cancers Symposium in January 2024.